Pharmacokinetic Modeling and Simulation in Drug Development

Abstract

Pharmacokinetic modeling and simulation have become indispensable tools in the process of drug development, offering a systematic approach to understanding the behavior of drugs within the body. This abstract explores the significance of pharmacokinetic modeling and simulation in various stages of drug development, encompassing drug discovery, preclinical studies, clinical trials, and post-marketing surveillance. In the initial stages of drug development, pharmacokinetic modeling aids in predicting drug behavior, optimizing dosing regimens, and selecting promising candidates for further investigation. Through preclinical studies, these models enable researchers to extrapolate findings from animal studies to human populations, facilitating informed decision-making regarding safety and efficacy.